The Mouse anti Human MMP-3 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to MMP3. This antibody recognizes Human antigen. The Mouse anti Human MMP-3 Antibody has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Mouse anti Human MMP-3 antibody, clone I08-9G7, recognizes matrix metalloproteinase-3 (MMP-3) also known as stromelysin-1 (SL-1) and transin-1. MMP-3 is a member of the metzincins superfamily of proteases and is produced by various cells and tissues including the endothelium, vascular smooth muscle cells intima and platelets (Cui et al. 2017).
MMP-3 is largely expressed by connective and vascular tissues and cells due to its roles in extracellular matrix remodeling. It is synthesized as a pre-proenzyme before being processed to remove the signal peptide forming the 57kDa pro-MMP-3. This is then further cleaved by proteolytic enzymes to create the 45kDa active form.
Like other MMP’s, MMP-3 plays a major role in tissue remodeling through the promotion of extracellular matrix (ECM) protein turnover. Specifically MMP-3 degrades the collagen proteins, type II, IV, IX as well as the proteoglycans elastin fibronectin and laminin (Cui et al. 2017). Through the degradation of these ECM components, growth factors and adhesion molecules, MMP-3 can modify the extracellular environment and modulate cell to cell signaling. As such, MMP-3 is implicated in synaptic plasticity through enzymatic modification of ECM constituents (Lech et al. 2019).
The purified Mouse anti Human MMP-3 antibody, clone I08-9G7 can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human MMP-3 antibody, clone G05-6A10 as the detection antibody